HitPredict

Interactor 1: ADAM9 (Q13443)
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase)
Gene: ADAM9

Interactor 2: SNX9 (Q9Y5X1)
Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A)
Gene: SNX9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	10531379, 25825872
Identification Methods	two hybrid, pull down, affinity chromatography technology, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0051044 - positive regulation of membrane protein ectodomain proteolysis GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 819 Hs			1 595
+	Hs
		1034713 ADAM9_HUMAN (1-819): 0: 681: 100.00		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		1034718 ADAM9_HUMAN (1-819): 0: 681: 100.00		SNX18_HUMAN (1-519): 3.5e-123: 379: 33.09
+	Hs
		197626 ADA12_HUMAN (26-815): 1.49e-172: 523: 35.50		SNX9_HUMAN (1-595): 5.31e-180: 523: 100.00
+	Hs
		1327036 ADA19_HUMAN (8-816): 5.44e-170: 518: 32.29		SNX9_HUMAN (1-595): 5.31e-180: 523: 100.00
+	Hs
		941718 ADAM8_HUMAN (18-814): 3.37e-170: 514: 30.63		SNX9_HUMAN (1-595): 5.31e-180: 523: 100.00
+	Hs
		1034782 ADA15_HUMAN (55-800): 4.78e-143: 445: 31.43		SNX9_HUMAN (1-595): 5.31e-180: 523: 100.00
+	Hs
		197615 ADA12_HUMAN (26-815): 1.49e-172: 523: 35.50		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		1261046 ADA19_HUMAN (8-816): 5.44e-170: 518: 32.29		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		941714 ADAM8_HUMAN (18-814): 3.37e-170: 514: 30.63		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		941716 ADAM8_HUMAN (18-814): 3.37e-170: 514: 30.63		SNX18_HUMAN (1-519): 3.5e-123: 379: 33.09
+	Hs
		1034764 ADA15_HUMAN (55-800): 4.78e-143: 445: 31.43		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		1300856 ATS1_HUMAN (38-661): 1.58e-101: 337: 19.57		SNX18_HUMAN (1-519): 3.5e-123: 379: 33.09
+	Hs
		1034755 ADA15_HUMAN (55-800): 4.78e-143: 445: 31.43		SNX30_HUMAN (169-592): 2.32e-74: 245: 17.82
+	Hs
		152355 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		SNX9_HUMAN (1-595): 5.31e-180: 523: 100.00
+	Hs
		944533 ADA17_HUMAN (140-517): 2.96e-19: 95.1: 24.61		SNX9_HUMAN (1-595): 5.31e-180: 523: 100.00
+	Hs
		152313 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		944513 ADA17_HUMAN (140-517): 2.96e-19: 95.1: 24.61		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		152323 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		SNX18_HUMAN (1-519): 3.5e-123: 379: 33.09
+	Hs
		944518 ADA17_HUMAN (140-517): 2.96e-19: 95.1: 24.61		SNX18_HUMAN (1-519): 3.5e-123: 379: 33.09
+	Hs
		152211 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		GAS7_HUMAN (2-555): 3.16e-52: 187: 13.69