HitPredict

Interactor 1: ADA15 (Q13444)
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
Gene: ADAM15

Interactor 2: SH3R3 (Q8TEJ3)
E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)
Gene: SH3RF3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	16374509
Identification Methods	pull down, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 863 Hs			1 882
+	Hs
		1034759 ADA15_HUMAN (1-863): 0: 556: 100.00		SH3R1_HUMAN (46-882): 1.03e-98: 330: 42.17
+	Hs
		1034778 ADA15_HUMAN (1-863): 0: 556: 100.00		RIM3A_HUMAN (56-882): 3.5e-41: 166: 11.03
+	Hs
		1034754 ADA15_HUMAN (1-863): 0: 556: 100.00		SPD2A_HUMAN (59-881): 2.54e-21: 102: 10.28
+	Hs
		1034751 ADA15_HUMAN (1-863): 0: 556: 100.00		ARHG6_HUMAN (769-882): 3.47e-19: 94.9: 19.30
+	Hs
		298978 ADA15_HUMAN (1-863): 0: 556: 100.00		SRBS2_HUMAN (523-882): 1.7e-18: 93.2: 14.79
+	Hs
		1034750 ADA15_HUMAN (1-863): 0: 556: 100.00		ARHG7_HUMAN (829-882): 7.71e-16: 84.1: 37.04
+	Hs
		1034753 ADA15_HUMAN (1-863): 0: 556: 100.00		ITSN1_HUMAN (571-882): 3.18e-13: 76.4: 8.31
+	Hs
		1034770 ADA15_HUMAN (1-863): 0: 556: 100.00		SH3G2_HUMAN (197-256): 3.94e-11: 67.4: 46.67
+	Hs
		1034780 ADA15_HUMAN (1-863): 0: 556: 100.00		PACN3_HUMAN (762-880): 4.09e-10: 65.1: 20.00
+	Hs
		1034771 ADA15_HUMAN (1-863): 0: 556: 100.00		SRBS1_HUMAN (122-250): 1.3e-09: 64.4: 20.61
+	Hs
		197606 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		SPD2A_HUMAN (59-881): 2.54e-21: 102: 10.28
+	Hs
		298977 ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00		SRBS2_HUMAN (523-882): 1.7e-18: 93.2: 14.79
+	Mm
		1142116 ADAM9_MOUSE (1-832): 1.79e-174: 527: 31.47		SH3G2_MOUSE (197-256): 2.91e-11: 68.2: 46.67
+	Mm
		1142117 ADAM9_MOUSE (1-832): 1.79e-174: 527: 31.47		PACN3_MOUSE (827-880): 2.11e-09: 62.8: 34.55
+	Hs
		197604 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		SH319_HUMAN (166-251): 5.64e-14: 78.1: 29.07
+	Hs
		197601 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		ITSN1_HUMAN (571-882): 3.18e-13: 76.4: 8.31
+	Hs
		197624 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		ITSN2_HUMAN (778-882): 5.3e-12: 72.1: 19.63
+	Hs
		1034723 ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00		SH3G2_HUMAN (197-256): 3.94e-11: 67.4: 46.67
+	Hs
		1034743 ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00		PACN3_HUMAN (762-880): 4.09e-10: 65.1: 20.00
+	Hs
		197625 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		PACN3_HUMAN (762-880): 4.09e-10: 65.1: 20.00