HitPredict

Interactor 1: ADA15 (Q13444)
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
Gene: ADAM15

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	10531379
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 863 Hs			1 352
+	Mm
		1142116 ADAM9_MOUSE (1-832): 1.79e-174: 527: 31.47		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Hs
		1034723 ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Mm
		292357 ADA15_MOUSE (1-844): 1.51e-166: 507: 79.67		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Hs
		1307433 ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		1034781 ADA15_HUMAN (1-863): 0: 556: 100.00		SHLB1_HUMAN (10-347): 8.42e-72: 229: 24.50
+	Hs
		1034763 ADA15_HUMAN (1-863): 0: 556: 100.00		SH3R3_HUMAN (270-346): 9.24e-13: 71.3: 35.80
+	Hs
		1034759 ADA15_HUMAN (1-863): 0: 556: 100.00		SH3R1_HUMAN (287-346): 1.48e-12: 70.9: 42.19
+	Hs
		924546 ADA15_HUMAN (1-863): 0: 556: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		298978 ADA15_HUMAN (1-863): 0: 556: 100.00		SRBS2_HUMAN (296-347): 7.69e-10: 62.4: 51.92
+	Hs
		1034767 ADA15_HUMAN (1-863): 0: 556: 100.00		OSTF1_HUMAN (296-344): 1.44e-09: 59.3: 53.06
+	Mm
		1141131 ADA12_MOUSE (37-860): 1.32e-172: 524: 35.30		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Hs
		197596 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		152324 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		298977 ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00		SRBS2_HUMAN (296-347): 7.69e-10: 62.4: 51.92
+	Hs
		197604 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77
+	Hs
		941715 ADAM8_HUMAN (1-851): 5.57e-160: 489: 31.26		OSTF1_HUMAN (296-344): 1.44e-09: 59.3: 53.06
+	Hs
		152287 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06
+	Hs
		152244 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		HCLS1_HUMAN (9-348): 2.93e-36: 138: 14.69
+	Hs
		152272 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		152297 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77