HitPredict

Interactor 1: ADA15 (Q13444)
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
Gene: ADAM15

Interactor 2: PACN3 (Q9UKS6)
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)
Gene: PACSIN3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	16374509, 10531379
Identification Methods	pull down, two hybrid, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 863 Hs			1 424
+	Mm
		1142117 ADAM9_MOUSE (1-832): 1.79e-174: 527: 31.47		PACN3_MOUSE (1-424): 1.36e-93: 290: 94.34
+	Mm
		292358 ADA15_MOUSE (1-844): 1.51e-166: 507: 79.67		PACN3_MOUSE (1-424): 1.36e-93: 290: 94.34
+	Hs
		1034743 ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		197625 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		1356560 ADA18_HUMAN (36-691): 9.32e-125: 395: 25.83		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		1034753 ADA15_HUMAN (1-863): 0: 556: 100.00		ITSN1_HUMAN (30-424): 3.23e-15: 80.2: 10.78
+	Hs
		941711 ADAM8_HUMAN (1-851): 5.57e-160: 489: 31.26		CIP4_HUMAN (16-365): 9.77e-38: 146: 17.05
+	Hs
		152352 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		197601 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		ITSN1_HUMAN (30-424): 3.23e-15: 80.2: 10.78
+	Hs
		152327 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		PACN1_HUMAN (4-422): 1.04e-84: 267: 48.86
+	Hs
		1132434 ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00		FBP1L_HUMAN (190-421): 1.92e-12: 70.9: 13.82
+	Hs
		305115 ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00		RIMB1_HUMAN (280-423): 2.01e-09: 62.1: 18.71
+	Hs
		152353 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		PACN2_HUMAN (4-422): 2.86e-77: 249: 48.96
+	Hs
		941713 ADAM8_HUMAN (1-851): 5.57e-160: 489: 31.26		FBP1L_HUMAN (190-421): 1.92e-12: 70.9: 13.82
+	Hs
		941717 ADAM8_HUMAN (1-851): 5.57e-160: 489: 31.26		FNBP1_HUMAN (214-421): 7.83e-12: 69: 13.46
+	Hs
		152206 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		PPIP1_HUMAN (7-422): 4.41e-64: 213: 21.48
+	Hs
		152280 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		MYO1E_HUMAN (2-422): 5.28e-39: 151: 14.03
+	Hs
		944529 ADA17_HUMAN (348-534): 2.91e-20: 98.6: 32.29		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		152211 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		GAS7_HUMAN (363-422): 5.06e-10: 63.1: 34.43
+	Hs
		944521 ADA17_HUMAN (348-534): 2.91e-20: 98.6: 32.29		PACN1_HUMAN (4-422): 1.04e-84: 267: 48.86