HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: M3K21 (Q5TCX8)
Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)
Gene: MAP3K21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 1036
+	Hs
		972497 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		M3K12_HUMAN (103-895): 1.14e-123: 400: 24.51
+	Hs
		1018214 FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70		M3K12_HUMAN (103-895): 1.14e-123: 400: 24.51
+	Hs
		1018209 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		M3K12_HUMAN (103-895): 1.14e-123: 400: 24.51