HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: KSR2 (Q6VAB6)
Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)
Gene: KSR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 25036637
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 950
+	Hs
		259949 FKBP6_HUMAN (2-137): 2.27e-35: 135: 35.97		KSR2_HUMAN (1-950): 0: 804: 100.00
+	Hs
		872531 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		EPHB4_HUMAN (59-939): 9.29e-161: 499: 14.30
+	Hs
		542876 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		BRAF_HUMAN (325-942): 1.44e-134: 423: 22.19
+	Hs
		374182 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		488708 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		ARAF_HUMAN (321-949): 4.2e-127: 399: 22.12
+	Gg
		982843 Q646T7_CHICK (1-446): 2e-137: 404: 83.86		BRAF_CHICK (324-942): 1.32e-131: 416: 22.62
+	Hs
		374083 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		488688 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		ARAF_HUMAN (321-949): 4.2e-127: 399: 22.12
+	Hs
		118695 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		EPHA8_HUMAN (102-946): 1.04e-167: 517: 13.54
+	Hs
		542932 FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70		BRAF_HUMAN (325-942): 1.44e-134: 423: 22.19
+	Hs
		374114 PPID_HUMAN (249-414): 4.11e-51: 178: 24.55		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		375059 FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		118664 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		118681 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		ARAF_HUMAN (321-949): 4.2e-127: 399: 22.12
+	Hs
		1128922 FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51		EPHAA_HUMAN (79-939): 6.16e-152: 477: 14.54
+	Hs
		488716 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		ARAF_HUMAN (321-949): 4.2e-127: 399: 22.12
+	Hs
		373773 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49