HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: UBP49 (Q70CQ1)
Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49)
Gene: USP49

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	28363942, 34431227, 19615732, 25036637
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 688
+	Hs
		1035001 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		Q9H9C5_HUMAN (316-685): 5.42e-92: 298: 21.66
+	Hs
		259950 FKBP6_HUMAN (2-137): 2.27e-35: 135: 35.97		UBP49_HUMAN (1-688): 0: 584: 100.00
+	Hs
		684830 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		UBP49_HUMAN (1-688): 0: 584: 100.00
+	Hs
		684938 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		USP9X_HUMAN (246-656): 6.96e-84: 292: 20.09