HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	29395067, 35271311, 25036637
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 859
+	Mm
		1145401 FKBP5_MOUSE (1-457): 1.26e-140: 412: 86.87		AGO2_MOUSE (1-859): 0: 1219: 99.19
+	Hs
		972609 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		1035043 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1035002 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Hs
		1035009 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		59978 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		A4FVC0_HUMAN (72-859): 0: 1130: 100.00
+	Dm
		1103850 FKB59_DROME (20-450): 5.8e-123: 366: 40.69		Q32KD4_DROME (6-859): 0: 1136: 73.10
+	Hs
		118802 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1034966 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		PIWL1_HUMAN (23-826): 0: 751: 22.45
+	Hs
		1034939 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		PIWL2_HUMAN (5-821): 0: 735: 21.74
+	Hs
		1034913 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		PIWL4_HUMAN (22-822): 0: 686: 22.07
+	Dm
		1186010 FKB59_DROME (20-450): 5.8e-123: 366: 40.69		AGO3_DROME (31-826): 0: 638: 20.89
+	Hs
		684905 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		PIWL2_HUMAN (5-821): 0: 735: 21.74
+	Hs
		259953 FKBP6_HUMAN (2-137): 2.27e-35: 135: 35.97		PIWL4_HUMAN (22-822): 0: 686: 22.07
+	Dm
		1186011 Q9VPN5_DROME (265-393): 3.01e-20: 94.9: 19.38		AGO3_DROME (31-826): 0: 638: 20.89
+	Dm
		1369530 Q9VPN5_DROME (265-393): 3.01e-20: 94.9: 19.38		PIWI_DROME (5-826): 0: 628: 21.56