HitPredict

Interactor 1: ROCK1 (Q13464)
Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)
Gene: ROCK1

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	15231748
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003180 - aortic valve morphogenesis GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0046872 - metal ion binding and 1 others more... GO:0048156 - tau protein binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1354 Hs			1 467
+	Hs
		1035199 ROCK1_HUMAN (1-1354): 0: 886: 100.00		SMAD5_HUMAN (1-467): 0: 570: 55.45
+	Hs
		1035168 ROCK1_HUMAN (1-1354): 0: 886: 100.00		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		254477 ROCK2_HUMAN (7-1344): 0: 714: 64.97		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		1078680 LATS2_HUMAN (48-374): 4.7e-70: 258: 38.77		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		1035470 MRCKG_HUMAN (653-1224): 5.7e-42: 171: 11.43		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58