HitPredict

Interactor 1: TOP3A (Q13472)
DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)
Gene: TOP3A

Interactor 2: RMI1 (Q9H9A7)
RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75)
Gene: RMI1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Property	Details
Experiments	24509834, 26186194, 28514442, 33961781, 20064461, 16537486, 20826342, 20360068, 15775963, 20711169
Identification Methods	x-ray crystallography, affinity chromatography technology, transmission electron microscopy, molecular sieving, far western blotting, pull down, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	RMI1_N~Topoisom_bac
Common GO terms	GO:0000724 - double-strand break repair via homologous recombination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031422 - RecQ family helicase-topoisomerase III complex GO:0071139 - resolution of DNA recombination intermediates
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 625
+	Hs
		328960 TOP3B_HUMAN (33-757): 0: 909: 35.13		RMI1_HUMAN (1-625): 0: 898: 100.00
+	Hs
		1035355 TOP3A_HUMAN (1-1001): 0: 1445: 100.00		TDRD3_HUMAN (134-257): 1.19e-34: 141: 27.69
+	Dm
		332127 TOP3B_DROME (33-745): 0: 858: 33.42		Q9VUH8_DROME (31-259): 2.86e-52: 194: 22.59
+	Hs
		328957 TOP3B_HUMAN (33-757): 0: 909: 35.13		TDRD3_HUMAN (134-257): 1.19e-34: 141: 27.69
+	Ce
		247621 TOP3_CAEEL (33-640): 0: 783: 51.79		RMI1_CAEEL (9-404): 7.03e-46: 176: 18.82