HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 694 Hs			1 822
+	Mm
		546325 GAB1_MOUSE (1-694): 0: 544: 89.93		NTRK2_MOUSE (1-822): 0: 631: 93.92
+	Hs
		1035375 GAB1_HUMAN (1-694): 0: 547: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		607961 GAB1_HUMAN (1-694): 0: 547: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		384791 GAB1_HUMAN (1-694): 0: 547: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507983 GAB1_HUMAN (1-694): 0: 547: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		665234 GAB1_HUMAN (1-694): 0: 547: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		385735 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		434188 GAB1_HUMAN (1-694): 0: 547: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Mm
		724173 GAB1_MOUSE (1-694): 0: 544: 89.93		RET_MOUSE (493-820): 7.8e-113: 371: 35.88
+	Hs
		435634 GAB1_HUMAN (1-694): 0: 547: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		1035415 GAB1_HUMAN (1-694): 0: 547: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Hs
		1081607 PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		608137 PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		666592 GAB1_HUMAN (1-694): 0: 547: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Hs
		508062 PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		508203 PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		385750 PKHA6_HUMAN (5-495): 5.54e-58: 214: 13.33		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		609340 PKHS1_HUMAN (5-310): 1.59e-42: 162: 17.13		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		385546 PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		435765 PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95