HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 694 Hs			1 461
+	Mm
		1193573 GAB1_MOUSE (1-694): 0: 544: 89.93		Q80UI5_MOUSE (1-455): 3.56e-101: 311: 76.92
+	Hs
		655356 GAB1_HUMAN (1-694): 0: 547: 100.00		P85A_HUMAN (48-455): 9.1e-92: 295: 79.17
+	Mm
		643113 GAB1_MOUSE (1-694): 0: 544: 89.93		P85A_MOUSE (60-455): 4.12e-90: 291: 80.81
+	Hs
		129290 GAB1_HUMAN (1-694): 0: 547: 100.00		P85B_HUMAN (56-453): 2.19e-87: 283: 74.12
+	Hs
		129351 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		P85B_HUMAN (56-453): 2.19e-87: 283: 74.12
+	Hs
		411709 GAB1_HUMAN (1-694): 0: 547: 100.00		LCK_HUMAN (309-458): 5.54e-21: 97.3: 25.95
+	Hs
		442825 GAB1_HUMAN (1-694): 0: 547: 100.00		HCK_HUMAN (310-458): 1.43e-19: 93.1: 26.75
+	Hs
		433345 GAB1_HUMAN (1-694): 0: 547: 100.00		YES_HUMAN (317-459): 6.84e-19: 91.2: 23.72
+	Hs
		522965 GAB1_HUMAN (1-694): 0: 547: 100.00		SRC_HUMAN (323-459): 8.26e-19: 90.8: 24.14
+	Hs
		846468 GAB1_HUMAN (1-694): 0: 547: 100.00		BLK_HUMAN (285-458): 2.65e-18: 89.2: 23.50
+	Mm
		403466 GAB1_MOUSE (1-694): 0: 544: 89.93		SRC_MOUSE (323-459): 7.66e-19: 91.2: 24.14
+	Hs
		433750 GAB1_HUMAN (1-694): 0: 547: 100.00		LYN_HUMAN (298-458): 6.17e-18: 88.1: 24.85
+	Hs
		147519 GAB1_HUMAN (1-694): 0: 547: 100.00		SOCS6_HUMAN (47-165): 1.85e-17: 86.8: 31.06
+	Hs
		1035413 GAB1_HUMAN (1-694): 0: 547: 100.00		VAV3_HUMAN (44-159): 6.81e-16: 82.5: 30.17
+	Hs
		855792 GAB1_HUMAN (1-694): 0: 547: 100.00		VAV2_HUMAN (38-159): 4.46e-13: 73.7: 22.95
+	Hs
		548703 GAB1_HUMAN (1-694): 0: 547: 100.00		VAV_HUMAN (65-170): 4e-12: 70.6: 27.36
+	Hs
		1035394 GAB1_HUMAN (1-694): 0: 547: 100.00		SHC3_HUMAN (43-164): 3.62e-12: 70.2: 31.15
+	Hs
		562645 GAB1_HUMAN (1-694): 0: 547: 100.00		PLCG2_HUMAN (337-452): 6.98e-12: 69.8: 33.33
+	Hs
		523213 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		SRC_HUMAN (323-459): 8.26e-19: 90.8: 24.14
+	Hs
		434086 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		LYN_HUMAN (298-458): 6.17e-18: 88.1: 24.85