HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: SH23A (Q9BRG2)
SH2 domain-containing protein 3A (Novel SH2-containing protein 1)
Gene: SH2D3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 694 Hs			1 576
+	Hs
		275569 GAB1_HUMAN (1-694): 0: 547: 100.00		BCAR3_HUMAN (8-574): 0: 570: 35.42
+	Hs
		433345 GAB1_HUMAN (1-694): 0: 547: 100.00		YES_HUMAN (3-256): 8.44e-68: 231: 12.36
+	Hs
		522965 GAB1_HUMAN (1-694): 0: 547: 100.00		SRC_HUMAN (3-256): 7.28e-68: 231: 12.36
+	Mm
		403466 GAB1_MOUSE (1-694): 0: 544: 89.93		SRC_MOUSE (3-256): 8.05e-67: 228: 12.73
+	Hs
		433750 GAB1_HUMAN (1-694): 0: 547: 100.00		LYN_HUMAN (3-256): 5.16e-66: 225: 11.61
+	Hs
		442825 GAB1_HUMAN (1-694): 0: 547: 100.00		HCK_HUMAN (3-256): 5.43e-62: 215: 13.48
+	Hs
		411709 GAB1_HUMAN (1-694): 0: 547: 100.00		LCK_HUMAN (3-256): 1.89e-59: 207: 14.23
+	Hs
		846468 GAB1_HUMAN (1-694): 0: 547: 100.00		BLK_HUMAN (3-256): 3.11e-58: 204: 14.66
+	Hs
		788991 GAB1_HUMAN (1-694): 0: 547: 100.00		TEC_HUMAN (3-228): 4.74e-49: 181: 14.75
+	Hs
		802588 GAB1_HUMAN (1-694): 0: 547: 100.00		CRK_HUMAN (3-246): 6.1e-51: 179: 21.17
+	Hs
		802837 GAB1_HUMAN (1-694): 0: 547: 100.00		CRKL_HUMAN (7-246): 6.07e-48: 171: 16.17
+	Hs
		924547 GAB1_HUMAN (1-694): 0: 547: 100.00		GRB2_HUMAN (3-166): 7.35e-45: 159: 19.21
+	Hs
		1035411 GAB1_HUMAN (1-694): 0: 547: 100.00		SH22A_HUMAN (12-275): 5.29e-37: 143: 17.98
+	Mm
		292690 GAB1_MOUSE (1-694): 0: 544: 89.93		GRAP2_MOUSE (3-149): 8.65e-38: 144: 30.13
+	Hs
		581001 GAB1_HUMAN (1-694): 0: 547: 100.00		PLCG1_HUMAN (2-254): 6.27e-34: 139: 18.42
+	Hs
		426958 GAB1_HUMAN (1-694): 0: 547: 100.00		FES_HUMAN (3-114): 4.77e-32: 133: 34.82
+	Hs
		275195 GAB1_HUMAN (1-694): 0: 547: 100.00		GRAP2_HUMAN (3-149): 8.33e-34: 132: 29.94
+	Hs
		666100 GAB1_HUMAN (1-694): 0: 547: 100.00		SHC1_HUMAN (1-117): 5.09e-32: 132: 32.26
+	Hs
		1035394 GAB1_HUMAN (1-694): 0: 547: 100.00		SHC3_HUMAN (4-117): 3.68e-31: 129: 28.70
+	Mm
		957247 GAB1_MOUSE (1-694): 0: 544: 89.93		SHC1_MOUSE (1-118): 1.19e-31: 131: 32.00