HitPredict

Interactor 1: G5E884 (G5E884)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Gene: Pak1

Interactor 2: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	36681682, 15673687, 16368433, 14580336
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0030036 - actin cytoskeleton organization GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 544 Mm			1 192
+	Mm
		103575 G5E884_MOUSE (1-544): 0: 561: 100.00		RHOQ_MOUSE (4-187): 8.33e-85: 250: 64.13
+	Hs
		925244 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564505 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Mm
		103567 G5E884_MOUSE (1-544): 0: 561: 100.00		RAC2_MOUSE (1-192): 6.16e-83: 245: 91.67
+	Mm
		292040 PAK1_MOUSE (1-544): 0: 551: 98.17		RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00
+	Hs
		545350 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		1026226 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Rn
		723755 PAK1_RAT (1-544): 0: 563: 99.27		CDC42_RAT (1-192): 1.4e-78: 234: 70.31
+	Mm
		292041 PAK1_MOUSE (1-544): 0: 551: 98.17		RAC2_MOUSE (1-192): 6.16e-83: 245: 91.67
+	Mm
		103565 G5E884_MOUSE (1-544): 0: 561: 100.00		CDC42_MOUSE (1-192): 1.4e-78: 234: 70.31
+	Hs
		892345 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		950963 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		893957 PAK1_HUMAN (1-544): 0: 557: 99.08		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Mm
		292039 PAK1_MOUSE (1-544): 0: 551: 98.17		CDC42_MOUSE (1-192): 1.4e-78: 234: 70.31
+	Mm
		292048 PAK1_MOUSE (1-544): 0: 551: 98.17		RHOA_MOUSE (5-192): 1.43e-77: 231: 57.98
+	Mm
		925809 PAK2_MOUSE (3-543): 1.86e-172: 499: 74.49		RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00
+	Hs
		564507 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545351 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Rn
		1145152 PAK2_RAT (3-543): 3.07e-172: 499: 74.49		CDC42_RAT (1-192): 1.4e-78: 234: 70.31
+	Hs
		436282 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45