HitPredict

Interactor 1: G5E884 (G5E884)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Gene: Pak1

Interactor 2: RHOQ (Q8R527)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10)
Gene: RHOQ

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11309621
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005884 - actin filament GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 544 Mm			1 205
+	Hs
		1026226 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOJ_HUMAN (9-204): 1.96e-108: 311: 79.59
+	Mm
		103565 G5E884_MOUSE (1-544): 0: 561: 100.00		CDC42_MOUSE (10-193): 2.94e-95: 276: 67.39
+	Mm
		292039 PAK1_MOUSE (1-544): 0: 551: 98.17		CDC42_MOUSE (10-193): 2.94e-95: 276: 67.39
+	Rn
		723755 PAK1_RAT (1-544): 0: 563: 99.27		CDC42_RAT (9-193): 5.39e-80: 238: 67.03
+	Hs
		564505 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOQ_HUMAN (1-205): 1.66e-81: 242: 99.51
+	Hs
		893957 PAK1_HUMAN (1-544): 0: 557: 99.08		CDC42_HUMAN (9-193): 5.39e-80: 238: 67.03
+	Mm
		103566 G5E884_MOUSE (1-544): 0: 561: 100.00		RAC1_MOUSE (10-195): 3.63e-78: 233: 63.44
+	Hs
		925244 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC1_HUMAN (10-195): 3.63e-78: 233: 63.44
+	Mm
		103567 G5E884_MOUSE (1-544): 0: 561: 100.00		RAC2_MOUSE (10-196): 6.36e-75: 225: 60.96
+	Mm
		292040 PAK1_MOUSE (1-544): 0: 551: 98.17		RAC1_MOUSE (10-195): 3.63e-78: 233: 63.44
+	Hs
		545350 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC2_HUMAN (10-196): 1.49e-74: 224: 61.50
+	Hs
		892345 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC3_HUMAN (10-183): 2.94e-74: 223: 66.09
+	Hs
		950963 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOG_HUMAN (9-204): 2.29e-73: 221: 52.04
+	Mm
		292041 PAK1_MOUSE (1-544): 0: 551: 98.17		RAC2_MOUSE (10-196): 6.36e-75: 225: 60.96
+	Mm
		292048 PAK1_MOUSE (1-544): 0: 551: 98.17		RHOA_MOUSE (1-204): 5.4e-75: 225: 49.51
+	Hs
		564507 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RHOQ_HUMAN (1-205): 1.66e-81: 242: 99.51
+	Rn
		1145152 PAK2_RAT (3-543): 3.07e-172: 499: 74.49		CDC42_RAT (9-193): 5.39e-80: 238: 67.03
+	Mm
		925809 PAK2_MOUSE (3-543): 1.86e-172: 499: 74.49		RAC1_MOUSE (10-195): 3.63e-78: 233: 63.44
+	Hs
		545351 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RAC2_HUMAN (10-196): 1.49e-74: 224: 61.50
+	Hs
		436282 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RHOC_HUMAN (1-192): 5.32e-73: 220: 51.04