HitPredict

Interactor 1: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 20447407, 18022362, 18570872, 25527291, 30181285, 30561431, 23166698, 11907583, 21549626, 19810754, 21113135, 21048196, 21331077, 22021857, 21393245, 22493164, 24975362, 25065467, 14960576, 18230607 and 2 others

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Identification Methods x-ray crystallography, enzymatic study, affinity chromatography technology, biochemical, two hybrid, pull down, bio-layer interferometry, molecular sieving, x ray scattering, light scattering and 2 others

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Interaction Type association, direct interaction, physical association, ubiquitination reaction

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~BIR, BIR~zf-C3HC4_3, CARD~CARD, CARD~zf-C3HC4_3, zf-C3HC4_3~zf-C3HC4_3
Common GO terms GO:0000209 - protein polyubiquitination
GO:0001666 - response to hypoxia
GO:0001741 - XY body
GO:0001890 - placenta development
GO:0003713 - transcription coactivator activity
and 44 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024