HitPredict

Interactor 1: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Interactor 2: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	30561431
Identification Methods	affinity chromatography technology, virotrap
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005737 - cytoplasm GO:1902523 - positive regulation of protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Hs			1 145
+	Hs
		849322 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		919722 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06
+	Hs
		895788 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06
+	Hs
		927749 BIRC2_HUMAN (1-618): 0: 702: 100.00		UBE2B_HUMAN (7-144): 2.17e-57: 177: 20.86
+	Hs
		1033104 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2V1_HUMAN (3-145): 3.5e-55: 171: 89.51
+	Hs
		1206094 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27
+	Hs
		849363 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		849321 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		919776 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06
+	Hs
		895841 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06
+	Hs
		919721 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06
+	Hs
		895787 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06
+	Hs
		1033103 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2V1_HUMAN (3-145): 3.5e-55: 171: 89.51
+	Hs
		930197 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UBC9_HUMAN (7-143): 1.02e-54: 170: 21.01
+	Mm
		620834 MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21		UB2D1_MOUSE (10-145): 2.2e-59: 182: 24.82
+	Hs
		849309 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Mm
		620833 MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21		UB2D3_MOUSE (10-144): 9.91e-58: 178: 22.06
+	Hs
		828987 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UBE2A_HUMAN (7-144): 6.23e-58: 178: 21.58
+	Hs
		851803 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2E1_HUMAN (1-143): 2.16e-56: 176: 22.92
+	Mm
		620837 MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21		UBC9_MOUSE (7-143): 1.02e-54: 170: 21.01