HitPredict

Interactor 1: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17220297
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 618 Hs			1 1374
+	Hs
		177716 BIRC5_HUMAN (267-346): 2.28e-22: 95.4: 34.12		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Hs
		1036333 BIRC2_HUMAN (1-618): 0: 702: 100.00		M3K3_HUMAN (685-940): 1.87e-43: 171: 40.08
+	Hs
		1036372 BIRC2_HUMAN (1-618): 0: 702: 100.00		M3K2_HUMAN (685-938): 1.31e-41: 165: 40.00
+	Hs
		160648 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36
+	Hs
		850640 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		KS6A3_HUMAN (623-1074): 1.34e-117: 387: 19.83
+	Hs
		962792 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		KS6A1_HUMAN (629-1074): 4.77e-113: 374: 18.70
+	Hs
		160517 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36
+	Hs
		160796 BIRC6_HUMAN (34-167): 3.57e-31: 132: 19.42		AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36
+	Hs
		160260 BIRC5_HUMAN (267-346): 2.28e-22: 95.4: 34.12		AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36
+	Hs
		1039177 BIRC6_HUMAN (34-167): 3.57e-31: 132: 19.42		KCC2D_HUMAN (678-995): 1.4e-97: 324: 26.53
+	Hs
		1026195 RFFL_HUMAN (567-618): 2.51e-17: 85.8: 42.31		PAK1_HUMAN (686-959): 2.31e-97: 325: 31.02
+	Hs
		957771 XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38		M3K3_HUMAN (685-940): 1.87e-43: 171: 40.08
+	Mm
		103631 XIAP_MOUSE (20-173): 1.62e-31: 130: 28.66		G5E8L8_MOUSE (685-938): 1.22e-41: 165: 40.15
+	Hs
		957801 XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38		M3K2_HUMAN (685-938): 1.31e-41: 165: 40.00
+	Mm
		620830 MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21		AKT1_MOUSE (438-615): 2e-25: 113: 14.14
+	Hs
		681795 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64
+	Hs
		681790 XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64
+	Hs
		682165 XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38		AKT2_HUMAN (438-620): 9.26e-25: 111: 13.24