HitPredict

Interactor 1: PICAL (Q13492)
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)
Gene: PICALM

Interactor 2: BMP2K (Q9NSY1)
BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1)
Gene: BMP2K

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	26496610, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 652 Hs			1 1161
+	Hs
		1036408 PICAL_HUMAN (1-652): 0: 606: 100.00		KS6A1_HUMAN (7-742): 2.04e-154: 480: 15.91
+	Hs
		161722 GAK_HUMAN (265-564): 6.12e-11: 68.1: 12.50		BMP2K_HUMAN (1-1161): 0: 1006: 100.00
+	Hs
		850650 PICAL_HUMAN (1-652): 0: 606: 100.00		KS6A3_HUMAN (39-744): 1.5e-147: 462: 16.80
+	Hs
		272863 PICAL_HUMAN (1-652): 0: 606: 100.00		KS6A4_HUMAN (20-781): 4.8e-130: 417: 14.23
+	Hs
		161653 PICAL_HUMAN (1-652): 0: 606: 100.00		GAK_HUMAN (23-313): 2.04e-42: 171: 40.26
+	Sc
		756309 AP18A_YEAST (20-569): 4.3e-101: 323: 20.95		ARK1_YEAST (35-336): 1.38e-51: 195: 37.06
+	Sc
		756304 AP18A_YEAST (20-569): 4.3e-101: 323: 20.95		PRK1_YEAST (43-327): 2.35e-49: 191: 37.29
+	Sc
		861369 AP18B_YEAST (20-566): 6.54e-98: 313: 19.46		ARK1_YEAST (35-336): 1.38e-51: 195: 37.06
+	Sc
		774607 AP18B_YEAST (20-566): 6.54e-98: 313: 19.46		PRK1_YEAST (43-327): 2.35e-49: 191: 37.29
+	Sc
		743873 AP18A_YEAST (20-569): 4.3e-101: 323: 20.95		AKL1_YEAST (43-327): 1.85e-42: 171: 36.39
+	Hs
		161665 GAK_HUMAN (265-564): 6.12e-11: 68.1: 12.50		AAK1_HUMAN (41-694): 1.99e-122: 402: 49.05
+	Hs
		124341 HIP1_HUMAN (10-299): 3.19e-82: 281: 14.61		GAK_HUMAN (23-313): 2.04e-42: 171: 40.26
+	Hs
		161596 HIP1R_HUMAN (13-329): 2.6e-78: 271: 12.35		GAK_HUMAN (23-313): 2.04e-42: 171: 40.26
+	Sc
		704796 SLA2_YEAST (16-396): 3.61e-69: 244: 14.90		ARK1_YEAST (35-336): 1.38e-51: 195: 37.06
+	Sc
		704785 SLA2_YEAST (16-396): 3.61e-69: 244: 14.90		PRK1_YEAST (43-327): 2.35e-49: 191: 37.29
+	Sc
		704775 SLA2_YEAST (16-396): 3.61e-69: 244: 14.90		AKL1_YEAST (43-327): 1.85e-42: 171: 36.39
+	Hs
		108854 H0YEF7_HUMAN (299-604): 2.9e-42: 156: 98.37		GAK_HUMAN (23-313): 2.04e-42: 171: 40.26
+	Hs
		161692 DEN1A_HUMAN (216-643): 2.06e-23: 107: 13.96		GAK_HUMAN (23-313): 2.04e-42: 171: 40.26
+	Hs
		161584 GAK_HUMAN (265-564): 6.12e-11: 68.1: 12.50		GAK_HUMAN (23-313): 2.04e-42: 171: 40.26