HitPredict

Interactor 1: PICAL (Q13492)
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)
Gene: PICALM

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	unassigned1973
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ANTH~ENTH
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0006897 - endocytosis and 1 others more... GO:0030276 - clathrin binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 652 Hs			1 576
+	Hs
		1036403 PICAL_HUMAN (1-652): 0: 606: 100.00		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		307529 PICAL_HUMAN (1-652): 0: 606: 100.00		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Hs
		255369 HIP1R_HUMAN (13-329): 2.6e-78: 271: 12.35		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Sc
		756319 AP18A_YEAST (20-569): 4.3e-101: 323: 20.95		ENT1_YEAST (3-228): 6.81e-62: 212: 36.73
+	Sc
		756314 AP18A_YEAST (20-569): 4.3e-101: 323: 20.95		ENT2_YEAST (3-538): 7.67e-59: 208: 19.59
+	Sc
		861383 AP18B_YEAST (20-566): 6.54e-98: 313: 19.46		ENT1_YEAST (3-228): 6.81e-62: 212: 36.73
+	Sc
		861375 AP18B_YEAST (20-566): 6.54e-98: 313: 19.46		ENT2_YEAST (3-538): 7.67e-59: 208: 19.59
+	Sc
		704813 SLA2_YEAST (16-396): 3.61e-69: 244: 14.90		ENT1_YEAST (3-228): 6.81e-62: 212: 36.73
+	Sc
		704805 SLA2_YEAST (16-396): 3.61e-69: 244: 14.90		ENT2_YEAST (3-538): 7.67e-59: 208: 19.59
+	Hs
		161657 GAK_HUMAN (265-564): 6.12e-11: 68.1: 12.50		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Dm
		113976 M9PB30_DROME (262-638): 5.8e-09: 61.9: 10.28		M9PB30_DROME (158-565): 6.46e-09: 61.2: 12.50