Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 25311206, 25416956, 25723488, 25686248, 26075355, 26187466, 26413874, 26902585, 26942676, 28359760, 29976090, 30120248, 30581152, 16169070, 32296183, 31375263, 31434890, 31857589, 33393215, 33545068 and 14 others

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Identification Methods affinity chromatography technology, two hybrid, x-ray crystallography, pull down, fluorescent resonance energy transfer, biochemical, protein complementation assay, proximity labelling technology, isothermal titration calorimetry, nuclear magnetic resonance and 5 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PB1~PB1, UBA_5~UBA_5, ZZ~ZZ
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000407 - phagophore assembly site
GO:0000422 - autophagy of mitochondrion
GO:0000423 - mitophagy
GO:0000425 - pexophagy
and 71 others

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Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 440
Hs

1 440
+ Rn
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Dr
+ Hs
+ Dr
+ Mm
+ Dr
+ Dm
+ Hs
+ Hs

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Last updated: 15 Jul 2024