HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	26743088, 34079125, 22674379
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0030674 - protein-macromolecule adaptor activity GO:0031625 - ubiquitin protein ligase binding GO:0044877 - protein-containing complex binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 745
+	Hs
		1036554 SQSTM_HUMAN (1-440): 0: 760: 100.00		CUL1_HUMAN (6-745): 0: 775: 36.24
+	Hs
		1036556 SQSTM_HUMAN (1-440): 0: 760: 100.00		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Mm
		1145367 SQSTM_MOUSE (1-440): 0: 731: 90.72		CUL3_MOUSE (1-745): 0: 768: 26.50
+	Hs
		1043086 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		1043444 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		1042234 MIB2_HUMAN (106-264): 3.55e-23: 104: 26.09		CUL3_HUMAN (1-745): 0: 768: 26.38