HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	12471037, 18457658
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 822
+	Mm
		546304 SQSTM_MOUSE (1-440): 0: 731: 90.72		NTRK2_MOUSE (1-822): 0: 631: 93.92
+	Hs
		1036607 SQSTM_HUMAN (1-440): 0: 760: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		609276 SQSTM_HUMAN (1-440): 0: 760: 100.00		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384793 SQSTM_HUMAN (1-440): 0: 760: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Rn
		139616 SQSTM_RAT (1-440): 0: 746: 90.95		NTRK1_RAT (45-822): 7.98e-173: 520: 47.85
+	Mm
		1112477 SQSTM_MOUSE (1-440): 0: 731: 90.72		NTRK1_MOUSE (45-822): 2.04e-173: 521: 47.09
+	Hs
		411378 SQSTM_HUMAN (1-440): 0: 760: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		385120 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		665280 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		434233 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		319859 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40