HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: SPRE2 (Q7Z698)
Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)
Gene: SPRED2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	27028858, 30771306, 19822672
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 418
+	Hs
		840468 SQSTM_HUMAN (1-440): 0: 760: 100.00		VASP_HUMAN (9-304): 1.74e-55: 189: 15.64
+	Hs
		1056067 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		SPRE2_HUMAN (1-418): 1.5e-175: 498: 100.00
+	Hs
		840474 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		VASP_HUMAN (9-304): 1.74e-55: 189: 15.64