HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: RBCC1 (Q8TDY2)
RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)
Gene: RB1CC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	33545068, 30853400, 34226595
Identification Methods	proximity labelling technology, pull down, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000407 - phagophore assembly site GO:0001934 - positive regulation of protein phosphorylation GO:0005829 - cytosol GO:0006914 - autophagy GO:0010508 - positive regulation of autophagy and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 1594
+	Hs
		1036861 SQSTM_HUMAN (1-440): 0: 760: 100.00		CP250_HUMAN (505-1593): 2.27e-40: 166: 10.73
+	Hs
		1036579 SQSTM_HUMAN (1-440): 0: 760: 100.00		GOGB1_HUMAN (584-1592): 5.4e-28: 126: 9.38
+	Hs
		148772 SQSTM_HUMAN (1-440): 0: 760: 100.00		CTRO_HUMAN (605-1125): 1.59e-12: 75.2: 10.62
+	Hs
		1036592 SQSTM_HUMAN (1-440): 0: 760: 100.00		PLEC_HUMAN (101-713): 3.96e-12: 74.1: 7.02
+	Hs
		1206000 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		RBCC1_HUMAN (1-1594): 9.92e-159: 526: 100.00
+	Hs
		319939 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		RBCC1_HUMAN (1-1594): 9.92e-159: 526: 100.00
+	Hs
		1056089 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		RBCC1_HUMAN (1-1594): 9.92e-159: 526: 100.00
+	Ce
		94013 F1LIM5_CAEEL (79-220): 6.58e-30: 124: 22.70		Q22342_CAEEL (276-1120): 2.05e-63: 240: 15.60
+	Hs
		1206041 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		CP250_HUMAN (505-1593): 2.27e-40: 166: 10.73
+	Hs
		319994 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		CP250_HUMAN (505-1593): 2.27e-40: 166: 10.73
+	Hs
		319864 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		GRDN_HUMAN (907-1591): 2.18e-17: 91.1: 10.32
+	Mm
		1118137 HERC2_MOUSE (120-197): 2.07e-12: 71.7: 32.50		MYH10_MOUSE (1179-1592): 3.09e-15: 84.1: 9.66
+	Hs
		319843 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		PLEC_HUMAN (101-713): 3.96e-12: 74.1: 7.02
+	Hs
		551704 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		DESP_HUMAN (899-1502): 4.19e-13: 77.2: 12.32
+	Mm
		1118160 HERC2_MOUSE (120-197): 2.07e-12: 71.7: 32.50		DYST_MOUSE (159-1538): 4.63e-10: 67.2: 9.49
+	Hs
		319988 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		AKAP9_HUMAN (793-1458): 2.62e-09: 64.5: 14.18