HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: TRIB3 (Q96RU7)
Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)
Gene: TRIB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	26268733, 31286822
Identification Methods	affinity chromatography technology, pull down, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PB1~Pkinase
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 358
+	Mm
		1145353 SQSTM_MOUSE (1-440): 0: 731: 90.72		TRIB3_MOUSE (1-358): 2e-147: 421: 73.18
+	Rn
		139624 SQSTM_RAT (1-440): 0: 746: 90.95		KPCL_RAT (17-356): 3.06e-132: 394: 19.10
+	Hs
		568653 SQSTM_HUMAN (1-440): 0: 760: 100.00		KAPCA_HUMAN (56-352): 4.79e-131: 380: 20.26
+	Hs
		1036686 SQSTM_HUMAN (1-440): 0: 760: 100.00		MARK2_HUMAN (13-355): 3.16e-123: 374: 22.32
+	Hs
		1036549 SQSTM_HUMAN (1-440): 0: 760: 100.00		KCC2D_HUMAN (61-317): 2.58e-23: 102: 28.47
+	Hs
		319892 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		MARK2_HUMAN (13-355): 3.16e-123: 374: 22.32
+	Hs
		568669 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		KAPCA_HUMAN (56-352): 4.79e-131: 380: 20.26