HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: GBRL1 (Q9H0R8)
Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
Gene: GABARAPL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.763

Property	Details
Experiments	32296183, 31006538, 34929165, 37219487, 20562859, 21617041, 21691068, 25416956, 16189514, 19250911, 17580304, 23022382, unassigned1304, unassigned3713
Identification Methods	two hybrid, affinity chromatography technology, unspecified method, anti tag coimmunoprecipitation, pull down, two hybrid prey pooling approach, two hybrid array, phage display, fluorescence polarization spectroscopy, validated two hybrid and 1 others more... two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005776 - autophagosome GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Hs			1 117
+	Hs
		891130 SQSTM_HUMAN (1-440): 0: 760: 100.00		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		1036661 SQSTM_HUMAN (1-440): 0: 760: 100.00		Q6IAW1_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		306157 SQSTM_HUMAN (1-440): 0: 760: 100.00		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		1036868 SQSTM_HUMAN (1-440): 0: 760: 100.00		MLP3C_HUMAN (5-116): 1.61e-44: 143: 39.47
+	Hs
		1036900 SQSTM_HUMAN (1-440): 0: 760: 100.00		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		1036882 SQSTM_HUMAN (1-440): 0: 760: 100.00		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		61895 SQSTM_HUMAN (1-440): 0: 760: 100.00		MP3B2_HUMAN (2-116): 6.71e-43: 138: 30.77
+	Mm
		1145358 SQSTM_MOUSE (1-440): 0: 731: 90.72		MLP3A_MOUSE (5-116): 1.09e-44: 142: 34.21
+	Mm
		1145362 SQSTM_MOUSE (1-440): 0: 731: 90.72		MLP3B_MOUSE (2-116): 3.03e-44: 141: 31.62
+	Hs
		306226 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Ce
		94010 F1LIM5_CAEEL (79-220): 6.58e-30: 124: 22.70		LGG1_CAEEL (1-116): 3.74e-55: 169: 78.45
+	Dm
		536028 REF2P_DROME (107-170): 7.35e-20: 94: 36.92		Q9W2S2_DROME (1-116): 1.56e-57: 175: 85.35
+	Ce
		94015 F1LIM5_CAEEL (79-220): 6.58e-30: 124: 22.70		LGG2_CAEEL (4-116): 6.14e-39: 128: 35.65
+	Hs
		891147 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		1056126 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		306175 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		320003 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		1056120 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		MLP3C_HUMAN (5-116): 1.61e-44: 143: 39.47
+	Hs
		1056129 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		1056123 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62