HitPredict

Interactor 1: MED21 (Q13503)
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)
Gene: MED21

Interactor 2: MED30 (Q96HR3)
Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)
Gene: MED30

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.55	0.706

The method score is based on:

Property	Details
Experiments	28514442, 24981860, 33961781, 35271311, 12584197, 15989967
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0003712 - transcription coregulator activity GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 8 others more... GO:0016592 - mediator complex GO:0016567 - protein ubiquitination GO:0032968 - positive regulation of transcription elongation by RNA polymerase II GO:0035019 - somatic stem cell population maintenance GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0061630 - ubiquitin protein ligase activity GO:0070847 - core mediator complex
Homologous interactions	0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024