HitPredict

Interactor 1: PRP4K (Q13523)
Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)
Gene: PRP4K

Interactor 2: PININ (Q9H307)
Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)
Gene: PNN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.727

Property	Details
Experiments	28514442, 33961781, 12077342, 35271311, 23602568
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 1007 Hs			1 717
+	Hs
		625598 CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45		PININ_HUMAN (1-717): 3.37e-144: 440: 100.00
+	Hs
		833972 CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05		PININ_HUMAN (1-717): 3.37e-144: 440: 100.00