HitPredict

Interactor 1: ATR (Q13535)
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)
Gene: ATR

Interactor 2: UHRF2 (Q96PU4)
E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2)
Gene: UHRF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	27114453, 33848395
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2644 Hs			1 802
+	Hs
		1038159 ATR_HUMAN (1-2644): 0: 2973: 100.00		UHRF1_HUMAN (1-802): 0: 817: 53.01
+	Hs
		1038114 ATR_HUMAN (1-2644): 0: 2973: 100.00		CHD4_HUMAN (294-594): 1.5e-54: 207: 12.84
+	Mm
		1143873 ATM_MOUSE (772-2644): 0: 1167: 18.64		UHRF1_MOUSE (1-802): 0: 789: 51.58
+	Hs
		944376 PRKDC_HUMAN (1676-2644): 1.8e-143: 506: 16.76		UHRF2_HUMAN (1-802): 0: 964: 100.00
+	Hs
		1031527 ATM_HUMAN (772-2644): 0: 1145: 18.85		CHD4_HUMAN (294-594): 1.5e-54: 207: 12.84
+	Hs
		782405 TRRAP_HUMAN (1161-2644): 0: 857: 13.71		KDM5C_HUMAN (251-428): 3.26e-34: 143: 16.36
+	Hs
		944209 PRKDC_HUMAN (1676-2644): 1.8e-143: 506: 16.76		CHD3_HUMAN (234-595): 1.54e-60: 225: 12.31
+	Hs
		944246 PRKDC_HUMAN (1676-2644): 1.8e-143: 506: 16.76		CHD4_HUMAN (294-594): 1.5e-54: 207: 12.84