HitPredict

Interactor 1: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Interactor 2: TAB2 (Q9NYJ8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
Gene: TAB2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	16603398, 15327770, 29955050, 18299187
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0010008 - endosome membrane GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 693
+	Hs
		201449 M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Rn
		473815 M3K7_RAT (4-611): 4.87e-124: 382: 18.87		TAB2_RAT (1-693): 1.35e-107: 343: 93.94
+	Mm
		1143268 M3K7_MOUSE (4-611): 1.21e-120: 373: 19.12		TAB2_MOUSE (1-693): 7.87e-108: 344: 94.66
+	Hs
		201369 M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Mm
		1123042 M3K7_MOUSE (4-611): 1.21e-120: 373: 19.12		TAB3_MOUSE (1-692): 2.76e-71: 247: 28.96
+	Hs
		201830 RIPK2_HUMAN (60-306): 4.47e-30: 127: 32.96		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		337335 ABL1_HUMAN (11-472): 1.06e-102: 340: 24.32		MUC1_HUMAN (23-434): 8.02e-18: 90.2: 8.89
+	Hs
		297808 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		K0754_HUMAN (24-414): 1.17e-27: 122: 10.30
+	Hs
		433853 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		MICA3_HUMAN (139-605): 2.54e-25: 114: 11.18
+	Hs
		433560 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		MUC1_HUMAN (23-434): 8.02e-18: 90.2: 8.89
+	Hs
		411582 LCK_HUMAN (23-289): 1.31e-27: 119: 31.87		MUC1_HUMAN (23-434): 8.02e-18: 90.2: 8.89
+	Mm
		93242 RIPK2_MOUSE (55-369): 5.14e-32: 132: 29.57		E9PWH2_MOUSE (175-521): 6.82e-12: 71.2: 12.37
+	Mm
		93243 Q547H1_MOUSE (55-369): 5.14e-32: 132: 29.57		E9PWH2_MOUSE (175-521): 6.82e-12: 71.2: 12.37
+	Hs
		203198 LCK_HUMAN (23-289): 1.31e-27: 119: 31.87		SYNJ1_HUMAN (303-658): 3.22e-09: 62.5: 9.55