HitPredict

Interactor 1: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Interactor 2: RIPK3 (Q9Y572)
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
Gene: RIPK3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 26319693, 23744296, 31358971, 34917906, 25882049, 24098568, 26786097, 29352166, 29497034, 29883609, 30420664, 10339433, 34942311, 34419074, 888800001028, 37085671, 21903422, 22864571, 26559832, 19524512 and 5 others

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Identification Methods affinity chromatography technology, protein complementation assay, two hybrid, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, protein kinase assay, molecular sieving, circular dichroism, electron microscopy and 3 others

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Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Pkinase
Common GO terms GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0032991 - protein-containing complex
and 11 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 671
Hs

1 518
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Last updated: 15 Jul 2024