HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: ARI5B (Q14865)
AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2)
Gene: ARID5B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.740

Property	Details
Experiments	26496610, 28514442, 33961781, 35271311, 34709266, 23752268
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 1188
+	Hs
		1060144 HDAC2_HUMAN (1-478): 0: 666: 85.92		ARI5B_HUMAN (1-1188): 0: 1901: 100.00
+	Hs
		782341 HDAC1_HUMAN (1-482): 0: 668: 100.00		KDM5C_HUMAN (238-549): 1.82e-70: 261: 18.21
+	Hs
		782369 HDAC2_HUMAN (1-478): 0: 666: 85.92		KDM5C_HUMAN (238-549): 1.82e-70: 261: 18.21
+	Mm
		140293 HDAC1_MOUSE (1-482): 0: 672: 99.38		KDM5B_MOUSE (243-528): 2.51e-61: 232: 16.89
+	Hs
		1038782 HDAC1_HUMAN (1-482): 0: 668: 100.00		KDM5B_HUMAN (243-535): 7.32e-62: 234: 17.82
+	Hs
		1270501 HDAC2_HUMAN (1-478): 0: 666: 85.92		KDM5B_HUMAN (243-535): 7.32e-62: 234: 17.82
+	Dm
		1276545 HDAC1_DROME (6-477): 0: 658: 77.33		KDM5_DROME (231-546): 1.22e-54: 211: 17.42
+	Hs
		666529 HDAC1_HUMAN (1-482): 0: 668: 100.00		KDM5A_HUMAN (240-509): 9.16e-51: 199: 18.15
+	Hs
		666546 HDAC2_HUMAN (1-478): 0: 666: 85.92		KDM5A_HUMAN (240-509): 9.16e-51: 199: 18.15
+	Mm
		57753 HDAC1_MOUSE (1-482): 0: 672: 99.38		ARI1A_MOUSE (307-567): 6.25e-39: 161: 15.65
+	Hs
		146213 HDAC1_HUMAN (1-482): 0: 668: 100.00		ARI1A_HUMAN (307-567): 1.84e-39: 162: 15.65
+	Mm
		57763 HDAC2_MOUSE (1-478): 0: 664: 85.71		ARI1A_MOUSE (307-567): 6.25e-39: 161: 15.65
+	Hs
		1038432 HDAC1_HUMAN (1-482): 0: 668: 100.00		ARI4B_HUMAN (323-536): 9.31e-37: 153: 24.89
+	Hs
		1117679 HDAC2_HUMAN (1-478): 0: 666: 85.92		ARI4B_HUMAN (323-536): 9.31e-37: 153: 24.89
+	Hs
		1270349 HDAC2_HUMAN (1-478): 0: 666: 85.92		JARD2_HUMAN (257-462): 9.34e-37: 153: 14.16
+	Hs
		666482 HDAC1_HUMAN (1-482): 0: 668: 100.00		ARI4A_HUMAN (321-537): 2.26e-32: 139: 19.82
+	Hs
		666500 HDAC2_HUMAN (1-478): 0: 666: 85.92		ARI4A_HUMAN (321-537): 2.26e-32: 139: 19.82
+	Sc
		693059 RPD3_YEAST (8-421): 0: 580: 61.48		ECM5_YEAST (254-599): 7.64e-49: 192: 15.13
+	Mm
		93520 Q9JM08_MOUSE (9-434): 0: 568: 57.71		ARI1B_MOUSE (318-568): 5.48e-43: 174: 15.54
+	Hs
		978219 HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56		ARI5A_HUMAN (324-594): 1.05e-52: 197: 35.02