HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: TNIP1 (Q15025)
TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)
Gene: TNIP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	29058807, 34709266, 36574265
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II GO:0043124 - negative regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 636
+	Hs
		1270533 HDAC2_HUMAN (1-478): 0: 666: 85.92		SMC3_HUMAN (278-527): 2.28e-43: 169: 25.09
+	Hs
		1038450 HDAC1_HUMAN (1-482): 0: 668: 100.00		MRCKA_HUMAN (38-480): 1.13e-18: 92.8: 12.23
+	Hs
		522611 HDAC1_HUMAN (1-482): 0: 668: 100.00		MYH7_HUMAN (19-585): 1.55e-18: 92.7: 9.12
+	Hs
		528410 HDAC1_HUMAN (1-482): 0: 668: 100.00		MYH8_HUMAN (2-475): 1.51e-17: 89.2: 8.75
+	Hs
		1038853 HDAC1_HUMAN (1-482): 0: 668: 100.00		MYH4_HUMAN (2-476): 3.89e-17: 88: 8.73
+	Hs
		522547 HDAC1_HUMAN (1-482): 0: 668: 100.00		MYH1_HUMAN (4-476): 1.16e-16: 86.5: 10.55
+	Hs
		148775 HDAC1_HUMAN (1-482): 0: 668: 100.00		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Hs
		1038808 HDAC1_HUMAN (1-482): 0: 668: 100.00		MYH2_HUMAN (4-512): 2.96e-16: 85.3: 11.98
+	Hs
		149134 HDAC2_HUMAN (1-478): 0: 666: 85.92		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Hs
		1038564 HDAC1_HUMAN (1-482): 0: 668: 100.00		RBCC1_HUMAN (161-525): 5.86e-15: 81.1: 17.12
+	Hs
		725212 HDAC2_HUMAN (1-478): 0: 666: 85.92		MYH10_HUMAN (210-571): 5.78e-13: 74.6: 10.48
+	Hs
		1038680 HDAC1_HUMAN (1-482): 0: 668: 100.00		CP250_HUMAN (63-566): 3.97e-11: 68.8: 11.57
+	Hs
		724813 HDAC1_HUMAN (1-482): 0: 668: 100.00		MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33
+	Hs
		724945 HDAC2_HUMAN (1-478): 0: 666: 85.92		MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33
+	Hs
		177316 HDAC3_HUMAN (9-434): 0: 574: 57.94		GRDN_HUMAN (154-540): 6.14e-09: 61.6: 9.92
+	Hs
		1316068 HDAC8_HUMAN (32-371): 2.54e-139: 407: 43.11		SMC3_HUMAN (278-527): 2.28e-43: 169: 25.09
+	Mm
		1208416 HDAC6_MOUSE (11-325): 4.35e-103: 334: 25.69		FTM_MOUSE (17-526): 3.12e-25: 113: 15.30
+	Mm
		1143175 HDAC6_MOUSE (11-325): 4.35e-103: 334: 25.69		MYH10_MOUSE (2-506): 2.12e-19: 95.4: 11.16
+	Hs
		725261 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		MYH10_HUMAN (210-571): 5.78e-13: 74.6: 10.48
+	Hs
		725053 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33