HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

The method score is based on:

Property	Details
Experiments	11641274, 17273746, 21148070, 24015760, 16511565
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 13 others more... GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0019899 - enzyme binding GO:0032991 - protein-containing complex GO:0042826 - histone deacetylase binding GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0070888 - E-box binding GO:2000273 - positive regulation of signaling receptor activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	482
Hs

1	826

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024