HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: RCOR2 (Q8IZ40)
REST corepressor 2
Gene: RCOR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	28514442, 33961781, 34709266, 23752268
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000118 - histone deacetylase complex GO:0003714 - transcription corepressor activity GO:0006357 - regulation of transcription by RNA polymerase II GO:0019899 - enzyme binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 523
+	Hs
		1038768 HDAC1_HUMAN (1-482): 0: 668: 100.00		RCOR3_HUMAN (46-520): 8.7e-129: 386: 57.20
+	Mm
		140317 HDAC1_MOUSE (1-482): 0: 672: 99.38		MTA2_MOUSE (12-512): 8.67e-104: 327: 17.14
+	Mm
		140301 HDAC1_MOUSE (1-482): 0: 672: 99.38		RCOR1_MOUSE (16-425): 1.84e-103: 320: 51.43
+	Hs
		296017 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA2_HUMAN (12-512): 1.27e-102: 324: 17.50
+	Hs
		296092 HDAC2_HUMAN (1-478): 0: 666: 85.92		MTA2_HUMAN (12-512): 1.27e-102: 324: 17.50
+	Hs
		1038801 HDAC1_HUMAN (1-482): 0: 668: 100.00		RCOR1_HUMAN (16-425): 1.79e-102: 318: 51.44
+	Mm
		140302 HDAC1_MOUSE (1-482): 0: 672: 99.38		MTA1_MOUSE (26-474): 3.01e-98: 314: 16.80
+	Hs
		1031849 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA1_HUMAN (26-474): 1.9e-97: 311: 17.00
+	Hs
		1031919 HDAC2_HUMAN (1-478): 0: 666: 85.92		MTA1_HUMAN (26-474): 1.9e-97: 311: 17.00
+	Hs
		1038676 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA3_HUMAN (17-421): 6.3e-95: 302: 15.66
+	Hs
		91458 HDAC1_HUMAN (1-482): 0: 668: 100.00		E7EQY4_HUMAN (17-359): 3.52e-91: 290: 18.55
+	Hs
		261500 HDAC1_HUMAN (1-482): 0: 668: 100.00		NCOR1_HUMAN (81-522): 1.27e-66: 236: 16.03
+	Hs
		1038770 HDAC1_HUMAN (1-482): 0: 668: 100.00		RERE_HUMAN (5-522): 2.54e-62: 223: 17.11
+	Hs
		1038488 HDAC1_HUMAN (1-482): 0: 668: 100.00		MIER3_HUMAN (2-233): 1.26e-60: 210: 22.05
+	Mm
		140291 HDAC1_MOUSE (1-482): 0: 672: 99.38		RERE_MOUSE (5-521): 4.38e-56: 205: 16.95
+	Hs
		1189328 HDAC2_HUMAN (1-478): 0: 666: 85.92		MIER3_HUMAN (2-233): 1.26e-60: 210: 22.05
+	Hs
		1038525 HDAC1_HUMAN (1-482): 0: 668: 100.00		MIER1_HUMAN (2-349): 3.51e-57: 200: 17.60
+	Hs
		1038636 HDAC1_HUMAN (1-482): 0: 668: 100.00		TREF1_HUMAN (14-305): 1.44e-31: 131: 22.15
+	Hs
		1038533 HDAC1_HUMAN (1-482): 0: 668: 100.00		MIER2_HUMAN (332-522): 1e-14: 78.9: 17.23
+	Hs
		1038852 HDAC1_HUMAN (1-482): 0: 668: 100.00		NCOR2_HUMAN (133-521): 1.5e-11: 69.3: 10.24