HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: MB3L2 (Q8NHZ7)
Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2)
Gene: MBD3L2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	33961781, 15701600
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0006346 - DNA methylation-dependent heterochromatin formation GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 208
+	Hs
		1246255 HDAC2_HUMAN (1-478): 0: 666: 85.92		MB3L2_HUMAN (1-208): 5.51e-93: 272: 100.00
+	Hs
		328550 HDAC1_HUMAN (1-482): 0: 668: 100.00		MBD3_HUMAN (16-208): 4.64e-87: 260: 30.93
+	Hs
		328624 HDAC2_HUMAN (1-478): 0: 666: 85.92		MBD3_HUMAN (16-208): 4.64e-87: 260: 30.93
+	Mm
		936430 HDAC2_MOUSE (1-478): 0: 664: 85.71		MBD3_MOUSE (16-208): 3.74e-88: 262: 31.44
+	Hs
		1038773 HDAC1_HUMAN (1-482): 0: 668: 100.00		MBD2_HUMAN (16-203): 4.85e-78: 241: 30.16
+	Hs
		1270493 HDAC2_HUMAN (1-478): 0: 666: 85.92		MBD2_HUMAN (16-203): 4.85e-78: 241: 30.16
+	Hs
		1038575 HDAC1_HUMAN (1-482): 0: 668: 100.00		MB3L1_HUMAN (23-207): 2.17e-79: 237: 40.96
+	Hs
		1263070 HDAC2_HUMAN (1-478): 0: 666: 85.92		MB3L1_HUMAN (23-207): 2.17e-79: 237: 40.96
+	Dm
		1276539 HDAC1_DROME (6-477): 0: 658: 77.33		Q9VHB7_DROME (41-194): 7.97e-60: 192: 27.22