HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: GCN1 (Q92616)
Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)
Gene: GCN1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26949739, 34709266
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 2671
+	Hs
		1270353 HDAC2_HUMAN (1-478): 0: 666: 85.92		TNPO1_HUMAN (908-1705): 1.2e-50: 198: 13.59
+	Sp
		140555 PHD1_SCHPO (7-415): 0: 524: 52.91		EF3_SCHPO (1403-1734): 1.93e-84: 304: 26.88
+	Hs
		127260 HDAC1_HUMAN (1-482): 0: 668: 100.00		IPO5_HUMAN (1381-2409): 4.59e-37: 155: 12.18
+	Hs
		127332 HDAC2_HUMAN (1-478): 0: 666: 85.92		IPO5_HUMAN (1381-2409): 4.59e-37: 155: 12.18
+	Hs
		672417 HDAC1_HUMAN (1-482): 0: 668: 100.00		2AAB_HUMAN (2265-2670): 2.67e-36: 149: 14.67
+	Hs
		177156 HDAC3_HUMAN (9-434): 0: 574: 57.94		SF3B1_HUMAN (1238-2069): 1.02e-61: 236: 13.97
+	Hs
		672112 HDAC1_HUMAN (1-482): 0: 668: 100.00		2AAA_HUMAN (959-1405): 1.51e-19: 97.8: 12.22
+	Hs
		1038365 HDAC1_HUMAN (1-482): 0: 668: 100.00		CKAP5_HUMAN (953-1968): 8.99e-11: 70.1: 10.33
+	Hs
		1038453 HDAC1_HUMAN (1-482): 0: 668: 100.00		ECM29_HUMAN (1769-2544): 4.52e-09: 64.6: 12.24
+	Sp
		140664 PHD1_SCHPO (7-415): 0: 524: 52.91		SF3B1_SCHPO (1363-2087): 2.53e-13: 78.3: 17.21