HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: ZN516 (Q92618)
Zinc finger protein 516
Gene: ZNF516

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	28514442, 33961781, 35271311, 34709266, 23752268, 28947780
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0045893 - positive regulation of DNA-templated transcription GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 1163
+	Hs
		1268295 HDAC2_HUMAN (1-478): 0: 666: 85.92		ZN516_HUMAN (1-1163): 0: 1179: 100.00
+	Hs
		167156 HDAC1_HUMAN (1-482): 0: 668: 100.00		ZN536_HUMAN (25-590): 1.04e-85: 306: 37.15
+	Hs
		260378 HDAC1_HUMAN (1-482): 0: 668: 100.00		ZN217_HUMAN (169-600): 3.48e-51: 199: 33.95
+	Hs
		260391 HDAC2_HUMAN (1-478): 0: 666: 85.92		ZN217_HUMAN (169-600): 3.48e-51: 199: 33.95
+	Hs
		1038772 HDAC1_HUMAN (1-482): 0: 668: 100.00		ZN219_HUMAN (36-314): 2.6e-30: 130: 31.65
+	Hs
		1270492 HDAC2_HUMAN (1-478): 0: 666: 85.92		ZN219_HUMAN (36-314): 2.6e-30: 130: 31.65
+	Mm
		93752 HDAC1_MOUSE (1-482): 0: 672: 99.38		ZN431_MOUSE (22-298): 1.26e-13: 77: 25.44
+	Mm
		93753 HDAC2_MOUSE (1-478): 0: 664: 85.71		ZN431_MOUSE (22-298): 1.26e-13: 77: 25.44