HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: PHB2 (Q99623)
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
Gene: PHB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15140878, 15173318
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0032991 - protein-containing complex GO:0043066 - negative regulation of apoptotic process GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 299
+	Mm
		140199 HDAC1_MOUSE (1-482): 0: 672: 99.38		PHB2_MOUSE (1-299): 2.46e-109: 320: 100.00
+	Hs
		1270403 HDAC2_HUMAN (1-478): 0: 666: 85.92		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		718831 HDAC1_HUMAN (1-482): 0: 668: 100.00		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		177365 HDAC3_HUMAN (9-434): 0: 574: 57.94		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		1305304 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		719208 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		1305256 Q9H368_HUMAN (211-428): 8.31e-79: 246: 51.35		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		646330 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93