HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: ZHX3 (Q9H4I2)
Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3)
Gene: ZHX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 956
+	Hs
		1270442 HDAC2_HUMAN (1-478): 0: 666: 85.92		ZHX3_HUMAN (1-956): 0: 916: 100.00
+	Hs
		1038860 HDAC1_HUMAN (1-482): 0: 668: 100.00		ZHX2_HUMAN (1-946): 0: 697: 29.70
+	Hs
		1270550 HDAC2_HUMAN (1-478): 0: 666: 85.92		ZHX2_HUMAN (1-946): 0: 697: 29.70
+	Hs
		966974 HDAC1_HUMAN (1-482): 0: 668: 100.00		SATB1_HUMAN (363-825): 9.01e-62: 226: 14.29
+	Hs
		540844 HDAC1_HUMAN (1-482): 0: 668: 100.00		PO2F1_HUMAN (418-725): 2.66e-44: 174: 12.74
+	Hs
		1038810 HDAC1_HUMAN (1-482): 0: 668: 100.00		ZHX1_HUMAN (394-889): 8.48e-41: 164: 19.60
+	Hs
		1270520 HDAC2_HUMAN (1-478): 0: 666: 85.92		ZHX1_HUMAN (394-889): 8.48e-41: 164: 19.60
+	Hs
		1038497 HDAC1_HUMAN (1-482): 0: 668: 100.00		ZFHX4_HUMAN (263-949): 1.28e-14: 80.9: 10.44
+	Hs
		1038413 HDAC1_HUMAN (1-482): 0: 668: 100.00		ZFHX3_HUMAN (213-841): 1.86e-13: 77.5: 11.23