HitPredict

Interactor 1: G5E9C8 (G5E9C8)
SOS Ras/Rac guanine nucleotide exchange factor 1 (Son of sevenless homolog 1 (Drosophila), isoform CRA_d)
Gene: SOS1

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1318 Hs			1 303
+	Hs
		802826 SOS1_HUMAN (1-1318): 0: 1031: 98.80		CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00
+	Mm
		815092 SOS1_MOUSE (1-1318): 0: 1022: 97.65		CRKL_MOUSE (1-303): 2.79e-72: 227: 96.70
+	Hs
		802575 SOS1_HUMAN (1-1318): 0: 1031: 98.80		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		580987 SOS1_HUMAN (1-1318): 0: 1031: 98.80		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		802827 SOS2_HUMAN (1-1317): 0: 920: 67.87		CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00
+	Mm
		1143290 SOS1_MOUSE (1-1318): 0: 1022: 97.65		PLCG1_MOUSE (5-224): 3.19e-29: 119: 16.95
+	Hs
		992475 SOS1_HUMAN (1-1318): 0: 1031: 98.80		GRAP_HUMAN (126-294): 1.63e-24: 100: 19.07
+	Hs
		992496 SOS1_HUMAN (1-1318): 0: 1031: 98.80		ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44
+	Hs
		557668 SOS1_HUMAN (1-1318): 0: 1031: 98.80		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Hs
		992489 SOS1_HUMAN (1-1318): 0: 1031: 98.80		SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69
+	Hs
		992505 SOS1_HUMAN (1-1318): 0: 1031: 98.80		CD2AP_HUMAN (242-303): 7.78e-13: 70.5: 28.57
+	Hs
		802576 SOS2_HUMAN (1-1317): 0: 920: 67.87		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		924511 SOS1_HUMAN (1-1318): 0: 1031: 98.80		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		209038 SOS1_HUMAN (1-1318): 0: 1031: 98.80		NCK2_HUMAN (72-204): 1.51e-09: 60.1: 21.48
+	Mm
		1141134 SOS1_MOUSE (1-1318): 0: 1022: 97.65		GRB2_MOUSE (240-295): 1.96e-10: 61.4: 26.32
+	Hs
		275188 SOS2_HUMAN (1-1317): 0: 920: 67.87		GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97
+	Hs
		580988 SOS2_HUMAN (1-1317): 0: 920: 67.87		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Mm
		970656 SOS2_MOUSE (1-1317): 0: 920: 67.49		PLCG2_MOUSE (5-192): 3.94e-27: 113: 18.72
+	Hs
		557669 SOS2_HUMAN (1-1317): 0: 920: 67.87		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Mm
		970654 SOS2_MOUSE (1-1317): 0: 920: 67.49		GRB2_MOUSE (240-295): 1.96e-10: 61.4: 26.32