HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: RERE (Q9P2R6)
Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)
Gene: RERE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	17150957, 16481466, 26496610, 28514442, 33961781, 23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl
Common GO terms	GO:0000118 - histone deacetylase complex GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 1566
+	Hs
		1270490 HDAC2_HUMAN (1-478): 0: 666: 85.92		RERE_HUMAN (29-1566): 0: 637: 100.00
+	Mm
		140291 HDAC1_MOUSE (1-482): 0: 672: 99.38		RERE_MOUSE (29-1566): 0: 624: 93.95
+	Hs
		91458 HDAC1_HUMAN (1-482): 0: 668: 100.00		E7EQY4_HUMAN (104-635): 2.09e-164: 508: 23.51
+	Hs
		1038676 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA3_HUMAN (104-705): 1.53e-156: 490: 22.17
+	Hs
		1270415 HDAC2_HUMAN (1-478): 0: 666: 85.92		MTA3_HUMAN (104-705): 1.53e-156: 490: 22.17
+	Hs
		1031849 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA1_HUMAN (104-687): 6.13e-137: 442: 22.72
+	Hs
		1031919 HDAC2_HUMAN (1-478): 0: 666: 85.92		MTA1_HUMAN (104-687): 6.13e-137: 442: 22.72
+	Mm
		140302 HDAC1_MOUSE (1-482): 0: 672: 99.38		MTA1_MOUSE (104-687): 1.3e-134: 435: 22.77
+	Mm
		936419 HDAC2_MOUSE (1-478): 0: 664: 85.71		MTA1_MOUSE (104-687): 1.3e-134: 435: 22.77
+	Mm
		140317 HDAC1_MOUSE (1-482): 0: 672: 99.38		MTA2_MOUSE (104-800): 7.16e-130: 421: 19.19
+	Hs
		296017 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA2_HUMAN (104-800): 1.6e-128: 417: 19.33
+	Mm
		936428 HDAC2_MOUSE (1-478): 0: 664: 85.71		MTA2_MOUSE (104-800): 7.16e-130: 421: 19.19
+	Hs
		296092 HDAC2_HUMAN (1-478): 0: 666: 85.92		MTA2_HUMAN (104-800): 1.6e-128: 417: 19.33
+	Hs
		1038801 HDAC1_HUMAN (1-482): 0: 668: 100.00		RCOR1_HUMAN (284-584): 1.44e-53: 198: 16.56
+	Mm
		140301 HDAC1_MOUSE (1-482): 0: 672: 99.38		RCOR1_MOUSE (284-584): 3.55e-52: 193: 15.92
+	Hs
		1270515 HDAC2_HUMAN (1-478): 0: 666: 85.92		RCOR1_HUMAN (284-584): 1.44e-53: 198: 16.56
+	Mm
		936418 HDAC2_MOUSE (1-478): 0: 664: 85.71		RCOR1_MOUSE (284-584): 3.55e-52: 193: 15.92
+	Hs
		1038768 HDAC1_HUMAN (1-482): 0: 668: 100.00		RCOR3_HUMAN (286-775): 8.29e-44: 169: 14.26
+	Hs
		1270488 HDAC2_HUMAN (1-478): 0: 666: 85.92		RCOR3_HUMAN (286-775): 8.29e-44: 169: 14.26
+	Hs
		203227 HDAC1_HUMAN (1-482): 0: 668: 100.00		SYNJ1_HUMAN (1216-1550): 2.72e-09: 64.5: 11.11