HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: IKZF2 (Q9UKS7)
Zinc finger protein Helios (Ikaros family zinc finger protein 2)
Gene: IKZF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 526
+	Hs
		1270517 HDAC2_HUMAN (1-478): 0: 666: 85.92		IKZF2_HUMAN (1-526): 0: 696: 100.00
+	Hs
		1270436 HDAC2_HUMAN (1-478): 0: 666: 85.92		IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22
+	Hs
		1033633 HDAC1_HUMAN (1-482): 0: 668: 100.00		IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20
+	Hs
		1033690 HDAC2_HUMAN (1-478): 0: 666: 85.92		IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20
+	Hs
		1038805 HDAC1_HUMAN (1-482): 0: 668: 100.00		IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52
+	Hs
		1270518 HDAC2_HUMAN (1-478): 0: 666: 85.92		IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52
+	Hs
		177285 HDAC3_HUMAN (9-434): 0: 574: 57.94		IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20
+	Mm
		140300 HDAC1_MOUSE (1-482): 0: 672: 99.38		Q8C5P6_MOUSE (31-227): 4.19e-78: 248: 66.50
+	Mm
		936415 HDAC2_MOUSE (1-478): 0: 664: 85.71		Q8C5P6_MOUSE (31-227): 4.19e-78: 248: 66.50
+	Hs
		1260190 HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56		IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22
+	Hs
		1033686 HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56		IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20
+	Hs
		1260200 HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56		IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52
+	Hs
		1038742 HDAC1_HUMAN (1-482): 0: 668: 100.00		PRDM5_HUMAN (114-219): 9.82e-10: 63.2: 29.25