HitPredict

Interactor 1: KCC2D (Q13557)
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Gene: CAMK2D

Interactor 2: ITPR2 (Q14571)
Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)
Gene: ITPR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	32707033, 29426014
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0033017 - sarcoplasmic reticulum membrane GO:0044325 - transmembrane transporter binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 499 Hs			1 2701
+	Hs
		1038963 KCC2G_HUMAN (1-478): 0: 646: 75.45		ITPR2_HUMAN (1-2701): 0: 4407: 100.00
+	Hs
		1055723 KCC2A_HUMAN (1-474): 0: 541: 87.37		ITPR2_HUMAN (1-2701): 0: 4407: 100.00
+	Hs
		1038965 KCC2G_HUMAN (1-478): 0: 646: 75.45		ITPR1_HUMAN (1-2695): 0: 3987: 68.01
+	Hs
		1038869 KCC2B_HUMAN (228-478): 1.5e-64: 223: 50.20		ITPR2_HUMAN (1-2701): 0: 4407: 100.00
+	Hs
		1039063 KCC2D_HUMAN (1-499): 0: 606: 100.00		ITPR1_HUMAN (1-2695): 0: 3987: 68.01
+	Hs
		1038964 KCC2G_HUMAN (1-478): 0: 646: 75.45		ITPR3_HUMAN (4-2687): 0: 3912: 64.48
+	Hs
		1039062 KCC2D_HUMAN (1-499): 0: 606: 100.00		ITPR3_HUMAN (4-2687): 0: 3912: 64.48
+	Hs
		1055819 KCC2A_HUMAN (1-474): 0: 541: 87.37		ITPR3_HUMAN (4-2687): 0: 3912: 64.48
+	Hs
		1038870 KCC2B_HUMAN (228-478): 1.5e-64: 223: 50.20		ITPR3_HUMAN (4-2687): 0: 3912: 64.48
+	Mm
		93470 KCC2D_MOUSE (1-499): 0: 606: 100.00		RYR2_MOUSE (1746-2208): 6.15e-48: 193: 19.85
+	Hs
		1039134 KCC2D_HUMAN (1-499): 0: 606: 100.00		RYR2_HUMAN (1746-2208): 9.59e-48: 192: 19.85