HitPredict

Interactor 1: KCC2D (Q13557)
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Gene: CAMK2D

Interactor 2: KCC2A (Q9UQM7)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: CAMK2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 28514442, 33961781, 25852190, 17353931, 32296183, 31980649, 32707033, 20668654, 29426014, unassigned1304, unassigned2173
Identification Methods affinity chromatography technology, two hybrid, cosedimentation in solution, anti tag coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti bait coimmunoprecipitation, pull down
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CaMKII_AD~CaMKII_AD, CaMKII_AD~Pkinase, Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 12 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 499
Hs

1 478
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+ Rn
+ Dm
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+ Gm
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+ Dm
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Last updated: 15 Jul 2024