HitPredict

Interactor 1: ULA1 (Q13564)
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)
Gene: NAE1

Interactor 2: TRIPC (Q14669)
E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)
Gene: TRIP12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	18627766
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0006974 - DNA damage response
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 534 Hs			1 1992
+	Hs
		125155 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		607135 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Hs
		48079 UBA6_HUMAN (1-373): 4.77e-48: 181: 18.54		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		48128 UBA6_HUMAN (1-373): 4.77e-48: 181: 18.54		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Hs
		131523 SAE1_HUMAN (6-265): 2.25e-73: 238: 24.03		IMA4_HUMAN (363-864): 7.19e-155: 489: 13.73
+	Hs
		983260 SAE1_HUMAN (6-265): 2.25e-73: 238: 24.03		UBE3A_HUMAN (1492-1991): 2.41e-140: 462: 27.02
+	Hs
		607104 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		HUWE1_HUMAN (1616-1992): 2.18e-25: 118: 28.72