HitPredict

Interactor 1: ULA1 (Q13564)
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)
Gene: NAE1

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	18264111, 17220875, 33857374, 16620772, 16503656, 21145461, 18274552
Identification Methods	x-ray crystallography, affinity chromatography technology, tandem affinity purification
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	ThiF~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0031625 - ubiquitin protein ligase binding GO:0045116 - protein neddylation
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 534 Hs			1 81
+	At
		790154 AXR1_ARATH (10-534): 1.97e-177: 512: 39.47		RUB1_ARATH (3-76): 7.75e-26: 94.5: 85.14
+	Hs
		1079547 UBA3_HUMAN (22-369): 1.13e-79: 258: 16.62		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		607051 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Sc
		408274 UBA1_YEAST (3-388): 4.13e-45: 172: 16.24		RS31_YEAST (1-70): 3.03e-30: 105: 52.86