HitPredict

Interactor 1: ULA1 (Q13564)
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)
Gene: NAE1

Interactor 2: UBE2F (Q969M7)
NEDD8-conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F)
Gene: UBE2F

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19250909
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ThiF~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0045116 - protein neddylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 534 Hs			1 185
+	Hs
		896070 ULA1_HUMAN (1-534): 0: 577: 100.00		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	At
		790153 AXR1_ARATH (10-534): 1.97e-177: 512: 39.47		RCE1_ARATH (17-162): 2.13e-28: 105: 38.78
+	Hs
		919796 UBA3_HUMAN (22-369): 1.13e-79: 258: 16.62		UB2D2_HUMAN (32-184): 5.23e-74: 220: 32.03
+	Hs
		1252654 UBA3_HUMAN (22-369): 1.13e-79: 258: 16.62		UBE2F_HUMAN (1-185): 3.02e-67: 205: 100.00
+	Hs
		782203 UBA7_HUMAN (4-315): 9.42e-60: 215: 18.77		UB2E1_HUMAN (9-184): 5.43e-70: 212: 27.27
+	Hs
		607190 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UB2D4_HUMAN (32-184): 2.15e-74: 221: 32.68
+	Hs
		607026 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		607050 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UB2D2_HUMAN (32-184): 5.23e-74: 220: 32.03
+	Hs
		607039 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		607136 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UB2E2_HUMAN (9-184): 1.68e-71: 216: 27.27
+	Hs
		607028 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UB2E1_HUMAN (9-184): 5.43e-70: 212: 27.27
+	Hs
		607129 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UB2E3_HUMAN (15-184): 2.12e-69: 211: 28.82
+	Sc
		854627 ULA1_YEAST (10-534): 4.22e-108: 332: 26.33		UBC12_YEAST (65-176): 8.72e-19: 81.3: 39.29
+	Hs
		607046 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UB2G1_HUMAN (33-182): 8.29e-66: 200: 30.19
+	Hs
		607023 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UBE2A_HUMAN (30-185): 1.58e-65: 199: 22.44
+	Hs
		607054 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UBE2B_HUMAN (30-184): 2.71e-64: 196: 22.58
+	Hs
		896154 UBA3_HUMAN (22-369): 1.13e-79: 258: 16.62		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Hs
		896245 SAE1_HUMAN (6-265): 2.25e-73: 238: 24.03		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Hs
		607040 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Dm
		1181845 Q7KSM5_DROME (6-254): 1.83e-55: 191: 24.34		UBC2M_DROME (9-181): 7.12e-34: 120: 38.73