HitPredict

Interactor 1: ULA1 (Q13564)
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)
Gene: NAE1

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 534 Hs			1 1024
+	Hs
		1252665 UBA3_HUMAN (22-369): 1.13e-79: 258: 16.62		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1353972 SAE1_HUMAN (6-265): 2.25e-73: 238: 24.03		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		607185 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		48142 UBA6_HUMAN (1-373): 4.77e-48: 181: 18.54		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		983260 SAE1_HUMAN (6-265): 2.25e-73: 238: 24.03		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		125155 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		607135 UBA1_HUMAN (1-384): 5.4e-56: 204: 20.61		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		48079 UBA6_HUMAN (1-373): 4.77e-48: 181: 18.54		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		48128 UBA6_HUMAN (1-373): 4.77e-48: 181: 18.54		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22